Discrimination

Your friend has a joke, shared with you and another lady.
You laughed and the other lady was like 'what joke is that' or 'is that a joke' or 'I don't understand what you're talking about'.
Usually, people would describe that lady as 'She's having her period'. That's sexual discrimination.

What if, the lady never laugh whenever she listen to a joke, which is considerably funny? People (and myself) would start saying that she must has a very sad childhood, where she was being bullied 24/7 from age 3 to 12 (After age 12, she would still feel that she's being bullied or isolated even if she's being told a joke). Is that a discrimination?